International Consensus Classification (ICC) of Myeloid Neoplasms227
| Myelodysplastic syndromes (MDS) and myelodysplastic syndrome/acute myeloid leukemia (MDS/AML)227 | ||||||
|---|---|---|---|---|---|---|
| Dysplastic Lineages | Cytopenias | Cytoses* | BM and PB blasts | Cytogenetics† | Mutations | |
| MDS with mutated SF3B1 (MDS-SF3B1) | Typically ≥ 1‡ | ≥1 | 0 | <5% BM <2% PB |
Any, except isolated del(5q), -7/del(7q), abn3q26.2, or complex | SF3B1 (≥ 10% VAF), without multi -hit TP53, or RUNX1 |
| MDS with del(5q) [MDS-del(5q)] |
Typically ≥ 1‡ | ≥1 | Thrombocytosis allowed | <5% BM <2% PB§ |
Del(5q), with up to 1 additional, except -7/del(7q) |
Any, except multi-hit TP53 |
| MDS, NOS without dysplasia |
0 | ≥1 | 0 | <5% BM <2% PB§ |
-7/del(7q) or complex | Any, except multi-hit TP53 or SF3B1 (≥ 10% VAF) |
| MDS, NOS with single lineage dysplasia | 1 | ≥1 | 0 | <5% BM <2% PB§ |
Any, except not meeting criteria for MDS-del(5q) |
Any, except multi-hit TP53; not meeting criteria for MDS-SF3B1 |
| MDS, NOS with multilineage dysplasia | ≥2 | ≥1 | 0 | <5% BM <2% PB§ |
Any, except not meeting criteria for MDS-del(5q) |
Any, except multi-hit TP53; not meeting criteria for MDS-SF3B1 |
| MDS with excess blasts (MDS-EB) | Typically ≥ 1‡ | ≥1 | 0 | 5-9% BM 5-9% PB§ |
Any | Any, except multi-hit TP53 |
| MDS/AML | Typically ≥ 1‡ | ≥1 | 0 | 10-19% BM or PB¶ | Any, except AML-defining# | Any, except NPM1, bZIP CEBPA or TP53 |
- CMML monocyte cut-off lower than WHO
- CMUS category added
- MDS/MPN-T-SF3B1
- MDS/MPN-RS-T-NOS
- MDS/MPN-NOS