Initial
Work-up Diagnosis
of MDS WHO/ICC
classification Prognostic Scoring:
IPSS Prognostic Scoring:
MPSS Prognostic Scoring
CCSS
Prognostic Scoring:
IPSS-R Prognostic Scoring:
IPSS-M Prognostic Scoring:
MDS-FI Other Prognostic
Factors Potential Future
Factors MDS Predisposing
Conditions
  • Adds transfusion requirement
  • Dynamic prognostic system (can be applied later in course of disease as variables change)

WHO Classification-Based Prognostic Scoring System for MDS49
Variable 0 1 2 3
WHO category RA, RARS, 5q- RCMD, RCMD-RS RAEB-1 RAEB-2
Karyotype* Good Intermediate Poor -
Transfusion requirement† No Regular - -

†RBC transfusion dependency was defined as having at least one RBC transfusion every 8 weeks over a period of 4 months.
*Good = normal, -Y, del(5q), del(20q)
Poor = complex (≥3 abnormalities), chromosome 7 anomalies
Intermediate = other abnormalities

Risk Category Score
Very low 0
Low 1
Intermediate 2
High 3-4
Very High 5-6
Survival Risk of Acute Leukemia WPSS
calculator