Initial
Work-up Diagnosis
of MDS WHO/ICC
classification Prognostic Scoring:
IPSS Prognostic Scoring:
WPSS Prognostic Scoring
CCSS
Prognostic Scoring:
IPSS-R Prognostic Scoring:
IPSS-M Prognostic Scoring:
MDS-FI Other Prognostic
Factors Potential Future
Factors MDS Predisposing
Conditions
  • Can be applied to any patients with MDS, including therapy related MDS, secondary MDS, and CMML
  • The MPSS is a dynamic scoring system and can be applied at any time during the disease

Simplified MDS Syndrome Risk Score (0-15 Points)*43
Prognostic Factor Coefficient Points
Performance status (ECOG)
≥2 0.267 2
Age, y
60-64 0.179 1
≥65 0.336 2
Platelets, X109/L
<30 0.418 3
30-49 0.270 2
50-199 0.184 1
Hemoglobin <12 g/dL 0.274 2
Bone marrow blasts, %
5-10 0.222 1
11-29 0.260 2
WBC >20 X109/L 0.258 2
Karyotype: Chromosome 7 abnormality or complex ≥3 abnormalities 0.479 3
Prior transfusion, yes 0.107 1
Risk Category Points
Low risk 0-4
Intermediate-1 risk 5-6
Intermediate-2 risk 7-8
High risk ≥9
Overall Survival (MPSS) MPSS
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