Initial
Work-up Diagnosis
of MDS WHO/ICC
classification Prognostic Scoring:
IPSS Prognostic Scoring:
WPSS Prognostic Scoring:
MPSS
Prognostic Scoring
CCSS Prognostic Scoring:
IPSS-M Prognostic Scoring:
MDS-FI Other Prognostic
Factors Potential Future
Factors MDS Predisposing
Conditions
Parameter Categories and Associated Scores30
Cytogenetic risk group* Very Good Good Intermediate Poor Very Poor
0 1 2 3 4
Marrow blast proportion ≤2% >2 - <5% 5 - 10% >10%
0 1 2 3
Hemoglobin ≥10 g/dL 8 - <10 g/dL <8 g/dL
0 1 1.5
Absolute neutrophil count ≥0.8 x 109/L <0.8 x 109/L
0 0.5
Platelet count ≥100 x 109/L 50 - 100 x 109/L <50 x 109/L
0 0.5 1

*Very good = -Y, del(11q); Good = Normal, del(5q), del(12p), del(20q), double including del(5q); Intermediate = del(7q), +8, +19, i(17q), any other single or double independent clones; Poor = -7, inv(3)/t(3q)/del(3q), double including -7/del(7q), complex: 3 abnormalities; Very poor = complex > 3 abnormalities.
Over the past 15 years our understanding of MDS has increased dramatically, and it has become clear that the IPSS significantly oversimplifies the biological and clinical heterogeneity of this disease. To address this deficiency, an analysis of over 7000 MDS patients combined from multiple international databases was performed to create a refined prognostic scoring system.

  • Added prognostic categories (5 vs. 3)
  • Improved predictive power with more precise prognostic subgroups
    (5 vs. 4)
  • Additional predictive features for survival
Overall
Survival Risk of
Progression
to AML IPSS-R
calculator