Initial
Work-up Diagnosis
of MDS WHO/ICC
classification Prognostic Scoring:
IPSS Prognostic Scoring:
WPSS Prognostic Scoring:
MPSS
Prognostic Scoring:
IPSS-R Prognostic Scoring:
IPSS-M Prognostic Scoring:
MDS-FI Other Prognostic
Factors Potential Future
Factors MDS Predisposing
Conditions
Risk Category Definition72
Very Good
  • del(11q) and –Y
  • Median OS, 60.8 months; HR, 0.5
Good
  • Normal, del(5q), del(12p), and del(20q) [all as a single anomaly] and double abnormalities including del(5q)
  • Median OS, 48.6 months; HR, 1.0
Intermediate
  • del(7q),8, i(17)(q10),19,21, any other single abnormality, independent clones, double abnormalities not harbouring del(5q) or 7/del(7q)
  • Median OS, 26.0 months; HR, 1.6
Poor
  • inv(3)/t(3q)/del(3q), 7, double abnormalities including 7/del(7q), and complex (i.e. three abnormalities)
  • Median OS, 15.8 months; HR, 2.6
Very Poor
  • Complex (i.e. three abnormalities)
  • Median OS, 5.9 months; HR, 4.2
  • Based on international data collection of 2902 patients
  • Incorporate 19 cytogenetic categories
Overall Survival AML-Free Survival