Initial
Work-up Diagnosis
of MDS WHO/ICC
classification Prognostic Scoring:
WPSS Prognostic Scoring:
MPSS Prognostic Scoring
CCSS
Prognostic Scoring:
IPSS-R Prognostic Scoring:
IPSS-M Prognostic Scoring:
MDS-FI Other Prognostic
Factors Potential Future
Factors MDS Predisposing
Conditions
  • Incorporates cytopenias, cytogenetics, BM blast count
  • Validated only for newly-diagnosed primary MDS*
IPSS for MDS: Survival and AML Evolution29
Score Value
Prognostic Variable 0 0.5 1.0 1.5 2.0
BM blasts (%) <5 5-10 - 11-20 21-30
Karyotype* Good Intermediate Poor
Cytopenias† 0/1 2/3

*Good = normal, -Y, del(5q), del(20q)
Poor = complex (≥3 abnormalities) or chromosome 7 anomalies
Intermediate = Other abnormalities (including +8, single miscellaneous, double abnormalities)
†Cytopenias were defined as a hemoglobin level of less than 100 g/L, an absolute neutrophil count of less than 1.5 x 109/L, and a platelet count of less than 100 x 109/L.

Risk Category Score
Lower-risk MDS Low risk 0
Intermediate-1 risk 0.5-1.0
Higher-risk MDS Intermediate-2 risk 1.5-2.0
High risk ≥2.5
Survival
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Evolution IPSS
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