Initial
Work-up Diagnosis
of MDS WHO/ICC
classification Prognostic Scoring:
IPSS Prognostic Scoring:
WPSS Prognostic Scoring:
MPSS Prognostic Scoring
CCSS Prognostic Scoring:
IPSS-R Prognostic Scoring:
IPSS-M Other Prognostic
Factors Potential Future
Factors MDS Predisposing
Conditions
Work-up Diagnosis
of MDS WHO/ICC
classification Prognostic Scoring:
IPSS Prognostic Scoring:
WPSS Prognostic Scoring:
MPSS Prognostic Scoring
CCSS Prognostic Scoring:
IPSS-R Prognostic Scoring:
IPSS-M Other Prognostic
Factors Potential Future
Factors MDS Predisposing
Conditions
- Frailty modifies prognosis in all MDS prognostic scoring systems.
- The most comprehensive method of assessing frailty is via this 42-item scale.169 An abbreviated 15-item version of this scale is also available.181
Deficits in MDS-FI169
| Element | Definition of deficit | Weighting |
|---|---|---|
| RDW (%) | Deficit if out-of-hospital lab range (10-14.5) | 2 |
| LDH (IU/L) | Deficit if out-of-hospital lab range (100-250) | 2 |
| WBC (neutrophils & lymphocytes) | Deficit if out-of-hospital lab range | 1 |
| MCV (fL) | Deficit if out-of-hospital lab range (78-96) | 1 |
| Ferritin (µg/L) | Deficit if out-of-hospital lab range (20-400) | 1 |
| Reticulocyte count (x109/L) | Deficit if out-of-hospital lab range (30-110 x109/L) | 1 |
| ALP (IU/L) | Deficit if out-of-range of 40-120 IU/L | 1 |
| ALT (IU/L) | Deficit if > 1.5 x ULN (where ULN=31) | 1 |
| Bilirubin (µmol/L) | >1.5xULN (where ULN=25) | 1 |
| CrCl |
<30 mL/min = 1; 30-59 mL/min = 0.5; ≥ 60 mL/min = 0 |
|
| BMI |
<18.5 = 1 or ≥ 30 = 1; 25-29.9 = 0.5; 18.5-24.9 = 0 |
|
| Any cancer hx | Deficit if current or in the past | 1 |
| Plans, prepares, serves adequate meals independently | Deficit if unable | 1 |
| 4m walk test (time to walk 4m in seconds) |
> 6.67 = 1; 4-6.67 = 0.5; < 4 = 0 |
